This is one of the tip that you can use to remove the clutter from the desktop of your Mac. The default file save location of Screen Shots (Command+Shift+4) in Mac is on Desktop which should ideally been into a specific folder (this is what i think).
With the help of below commands you can change the location within 1 minute & without any hassel. Here are the steps:
Step1: Simply launch the Terminal and use the following syntax:
Step2: To implement the changes effects, use